Galante et al., 2023 Fig. 2
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Fig. 2 | IPD meta-analysis of the primary outcome (psychological distress at the 1–6 month follow-up, comparison with passive-control groups). Random-effects meta-analysis using the restricted maximum-likelihood (REML) method (two-sided test with no adjustment for multiple comparisons). Data are presented as SMD with 95% CIs. N = 2,371 participants.
A textbook-clean forest plot: thirteen trials, 2,371 participants, every point estimate on the favorable side of zero, and a pooled SMD of −0.32 (95% CI −0.41 to −0.24) with I² = 0%. It supports the 'reductions in psychological distress' part of the claim with the most recent and methodologically strongest design in the batch (individual participant data), and the near-zero heterogeneity makes it an unusually easy read for a non-specialist. It is partly redundant with Goyal Figure 1A — both are 'the evidence is favorable but modest' figures — so if the module wants only one, Goyal covers more outcome domains while Galante is the more current and more visually approachable. Showing both is defensible since Goyal is a breadth-of-domains summary and Galante is a depth-on-one-outcome forest plot.
systematic reviews and meta-analyses consistently report stress-related benefits from mindfulness-based programs. These include reductions in psychological distress, anxiety, and stress, along with favorable changes in cortisol, blood pressure, and heart rate (Goyal et al., 2014; Galante et al., 2023; Pascoe et al., 2017).
Goyal et al., 2014 Figure 1A
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Figure 1.
Figure 1A: Summary across measurement domains of comparisons of meditation programs with non-specific active controls
Figure 1B. Summary across measurement domains of comparisons of meditation programs with specific active controls
The widely reproduced summary figure from the JAMA Internal Medicine review: a combined table and forest plot giving, for each outcome domain (anxiety, depression, stress/distress, negative affect, quality of life, pain and others), the number of trials, total N, direction and magnitude of effect, and a GRADE strength-of-evidence rating, all against a 'favors meditation / favors control' axis. It is the best single figure in the batch for the module's 'reviews consistently report' sentence because it shows breadth and calibrated confidence at the same time — moderate evidence for anxiety, depression and pain; low or insufficient elsewhere. Two caveats for the authors: the caption text sits at the foot of the page rather than beneath the panel, so it is supplied here verbatim rather than inside the crop, and panel 1B (comparisons against specific active controls, almost all rated 'insufficient') was deliberately excluded; include it only if the module wants to make the point that meditation has not been shown superior to other active treatments.
systematic reviews and meta-analyses consistently report stress-related benefits from mindfulness-based programs. These include reductions in psychological distress, anxiety, and stress, along with favorable changes in cortisol, blood pressure, and heart rate (Goyal et al., 2014; Galante et al., 2023; Pascoe et al., 2017).
Taren et al., 2015 Fig. 2
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Fig. 2. Discovery study (a, top left panel) Greater self-reported perceived stress on the PSS (item average) is associated with greater rsFC between right amygdala and subgenual ACC (P < 0.001). (a, top right panel) Scatterplot between perceived stress and right amygdala-sgACC rsFC parameter estimates (n = 130, R = 0.15). (b, bottom left panel) Greater self-reported perceived stress on the PSS (item average) is associated with greater rsFC between left amygdala and ACC (P < 0.001). (b, bottom right panel) Scatterplot between perceived stress and left amygdala-sgACC rsFC parameter estimates (n = 130, R = 0.101).
Supports the first half of the claim. Sagittal brain slices with the subgenual ACC cluster highlighted in red, each paired with a scatterplot of Perceived Stress Scale score against amygdala-sgACC connectivity in the n = 130 discovery sample. A clinician sees immediately both where the effect is in the brain and that the relationship is a positive but modest linear trend. The brain-plus-scatter pairing is exactly the kind of anchor the module needs, and the visible scatter keeps the reader honest about effect size (R ≈ 0.10-0.15).
higher perceived stress has been associated with stronger resting connectivity between the amygdala and other stress-related brain regions. In a randomized trial, a three-day intensive mindfulness program reduced this functional coupling (Taren et al., 2015).
Taren et al., 2015 Fig. 3
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Fig. 3. Mindfulness Meditation Training RCT. The left panel depicts the region of sgACC that showed decreased rsFC with right amygdala from before to after mindfulness meditation training (HEM) relative to relaxation training (HER) (P < 0.05, corrected for multiple comparisons). The right panel depicts the mean percent signal change for subgenual ACC cluster for the mindfulness (HEM) and relaxation (HER) training groups at each of the two time points (pre- and post-intervention). Error bars depict ± 1 standard error. Parameter estimates were extracted in SPM8 and plotted in a random effects mixed model conducted in SPSS.
This is the randomized-trial figure that carries the second half of the claim. The right panel is the group x time interaction in its simplest possible form: four bars in which only Post-HEM (the 3-day mindfulness retreat arm) drops below zero while the matched relaxation-training arm stays positive. That contrast is readable in well under twenty seconds and makes the point that the effect is specific to the mindfulness component rather than to resting at a retreat. The left panel gives the anatomical location. This is the single best figure in the batch for this citation.
higher perceived stress has been associated with stronger resting connectivity between the amygdala and other stress-related brain regions. In a randomized trial, a three-day intensive mindfulness program reduced this functional coupling (Taren et al., 2015).
Wolfe et al., 2024 Table 2
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TABLE 2. Heart Rate Variability Change From Baseline Compared With Mindfulness Exercisesᵃ
ᵃn = 13 participants.
ᵇHeart rate variability metrics in gray are consistent with parasympathetic activation (relaxation).
ᶜContinuous long-term beat-to-beat interval variability sd 2 instantaneous beat-to-beat interval variability (sd 1).
Boldface values are statistically significant findings.
This is the paper's core result table: five HRV metrics (RMSSD, HF normalized, parasympathetic nervous system index, SD2/SD1 ratio, and stress index) measured at baseline and during each of three brief practices (grounding, deep breathing, body scan), with p values against baseline. It is the single clearest evidence for the module's claim, showing that short relaxation exercises shifted clinicians toward parasympathetic predominance and lowered the composite stress index. It is well designed, self-explanatory to a healthcare reader, and honest about the small sample (n = 13) in its own footnote. Note that deep breathing actually lowered HF, so the table is not uniformly positive, which is a useful nuance if the module wants it.
Evidence for this shift can be seen in a small study of pediatric nurses, nurse practitioners, and physicians. Brief relaxation practices were associated with lower self-reported stress and increased heart-rate variability, which is a physiological measure of improved parasympathetic function (Wolfe et al., 2024).
Khir et al., 2024 Figure 3
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Figure 3 The Efficacy of PMR on Stress, Anxiety and Depression.
Three pie charts showing the proportion of standalone PMR studies reporting a significant reduction in stress (93%, 14 of 15), anxiety (82%, 14 of 17) and depression (87%, 7 of 8). It maps directly onto the first half of the module sentence and is legible in about five seconds. Rated medium, not high, because it is vote counting rather than pooled effect sizes — it says how many studies found an effect, not how large the effect was — so it overstates certainty if presented without comment. Pair it with Figure 4 or caption it carefully.
progressive muscle relaxation... examined in a systematic review of 46 studies involving more than 3000 adults, which found the practice to be generally associated with reduced stress, anxiety, and depression (Khir et al., 2024). These benefits were often stronger when it was combined with other meditative skills.
Khir et al., 2024 Figure 4
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Figure 4 The Efficacy of PMR combined with other interventions on Stress, Anxiety and Depression.
The companion chart for PMR combined with other interventions (health education, music therapy, other relaxation techniques, deep breathing): 100% of studies reported reduced stress versus 93% for standalone PMR. This is the only figure in the paper that speaks to the module's second sentence about benefits being stronger in combination, so it earns its place alongside Figure 3 and the two should be shown as a pair. Same vote-counting caveat as Figure 3, and note honestly that the combined-intervention depression result is actually weaker (67% vs 87%), so the 'stronger in combination' claim holds for stress but not across all outcomes.
progressive muscle relaxation... examined in a systematic review of 46 studies involving more than 3000 adults, which found the practice to be generally associated with reduced stress, anxiety, and depression (Khir et al., 2024). These benefits were often stronger when it was combined with other meditative skills.
Pascoe et al., 2017 Fig 2
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Fig 2
The cortisol forest plot, pooled by time of day: waking −1.51 (−2.83, −0.19), afternoon −0.60 (−1.13, −0.06) and evening −0.88 (−1.75, −0.01) all favor the intervention, while mid-morning and diurnal slope do not. This is the only figure in the batch that evidences the 'favorable changes in cortisol' clause, so it is the non-redundant contribution Pascoe makes alongside Goyal and Galante. Rated medium: the PDF is an accepted manuscript, so the figure is a low-resolution raster with no descriptive caption beyond the bare label 'Fig 2', it is dense enough to push the twenty-second test, and most contributing trials are yoga rather than MBSR — the module should say 'yoga and mindfulness-based programs' if it cites this figure directly.
systematic reviews and meta-analyses consistently report stress-related benefits from mindfulness-based programs. These include reductions in psychological distress, anxiety, and stress, along with favorable changes in cortisol, blood pressure, and heart rate (Goyal et al., 2014; Galante et al., 2023; Pascoe et al., 2017).
Wolfe et al., 2024 Figure 2
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Figure 2. Poincarè plots demonstrating parasympathetic predominance (relaxation) during body scan exercise. A, Participant baseline torpedo shaped measurement consistent with sympathetic overdrive. B, Same participant demonstrating parasympathetic predominance, relaxation, during the body scan exercise. X-axis RRn (ms): RR interval, y-axis: RRn + 1 (ms): subsequent RR interval.
Two Poincarè plots from the same clinician, baseline versus body scan, where the narrow cigar-shaped cloud visibly opens into a broad ellipse. It is a strong visual anchor for what 'increased heart-rate variability' actually means, turning an abstract metric into a shape a reader can see change in a few seconds. Rated medium rather than high because it is a single participant, illustrative rather than inferential, and Poincarè plots are unfamiliar to most clinicians — it would need a one-line gloss in the module ('wider cloud = more beat-to-beat variability = more parasympathetic tone').
Evidence for this shift can be seen in a small study of pediatric nurses, nurse practitioners, and physicians. Brief relaxation practices were associated with lower self-reported stress and increased heart-rate variability, which is a physiological measure of improved parasympathetic function (Wolfe et al., 2024).
Pascoe et al., 2017 Fig 4
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Fig 4
The blood-pressure forest plot, with pooled estimates for resting diastolic BP −3.66 mmHg (−5.84, −1.48) and resting systolic BP −5.17 mmHg (−8.31, −2.03), each additionally split into MBSR and non-MBSR subgroups — the MBSR-specific stratification is the part that matters for this module. Included because blood pressure is named explicitly in the claim and no other paper in the batch covers it. Rated low for reproduction: at roughly sixty rows on a single low-resolution accepted-manuscript page it is far too dense for a textbook module, and the labels are only marginally legible even at high crop resolution. Recommendation is to quote the two pooled mmHg figures in the module text rather than reproduce this figure; ship it only if the authors want a visual and are willing to redraw it as a small summary graphic.
systematic reviews and meta-analyses consistently report stress-related benefits from mindfulness-based programs. These include reductions in psychological distress, anxiety, and stress, along with favorable changes in cortisol, blood pressure, and heart rate (Goyal et al., 2014; Galante et al., 2023; Pascoe et al., 2017).
No figurePDF is not present in /Users/corbin/Downloads/20260802-Module-2-PDFs/. Verified by directory listing and by filename search for 'benson' and '1974'; no match. No figure could be harvested for this citation.
PDF not in the folder
In the 1970s, Benson and colleagues first studied meditation not as a religious or contemplative practice but as a measurable physiological process... a wakeful state of lower metabolism, along with reductions in oxygen consumption, carbon dioxide output, breathing rate, and blood pressure (Wallace et al., 1971; Benson et al., 1974).
No figurePDF is not present in /Users/corbin/Downloads/20260802-Module-2-PDFs/. Directory listing and a filename search for 'wallace', 'benson', '1971' and '1974' returned no match, so no figure could be harvested. Worth sourcing: the Wallace, Benson & Wilson 1971 Am J Physiol paper contains the classic time-series traces of oxygen consumption, CO2 elimination and respiratory rate across pre-meditation / meditation / post-meditation periods, which would illustrate this exact claim better than any modern substitute.
PDF not in the folder
In the 1970s, Benson and colleagues first studied meditation not as a religious or contemplative practice but as a measurable physiological process... a wakeful state of lower metabolism, along with reductions in oxygen consumption, carbon dioxide output, breathing rate, and blood pressure (Wallace et al., 1971; Benson et al., 1974).